Risk Factors and Assessment of Blood Clots in Non-Hodgkin Lymphoma Patients
Author Information
Author(s): Wen Li, Liu Rui, Shen Ying, Gao GongZhizi, Yang Rui, Wang Yiwen, Yang Ruoyu, Lin Zujie, Dong Ruijun, Zhao Wanhong, He Aili, Bai Ju
Primary Institution: The Second Affiliated Hospital of Xi'an Jiaotong University
Hypothesis
What are the characteristics and predictive risk factors for venous thromboembolism (VTE) in newly diagnosed non-Hodgkin lymphoma patients?
Conclusion
The study identified independent risk factors for VTE in NHL patients and proposed a modified risk assessment model that effectively predicts VTE risk.
Supporting Evidence
- VTE developed in 7.09% of NHL patients.
- Independent risk factors for VTE included clinical Stage III/IV, mediastinal involvement, history of VTE, D-dimer≥ 1345 μg/dL, and platelet (PLT)≥ 298 × 109.
- The ThroLy score was improved by adjusting the hemoglobin cutoff and combining it with D-dimer testing.
- Sequential testing of TM and TAT achieved a sensitivity of 66.7%, specificity of 100%, positive predictive value of 100%, and negative predictive value of 96.7%.
Takeaway
This study found that some patients with non-Hodgkin lymphoma are at risk of developing blood clots, and it created a better way to predict who might get them.
Methodology
Data were collected from newly diagnosed NHL patients to analyze characteristics and potential predictive risk factors for VTE, and the clinical applicability of existing risk assessment models was evaluated.
Potential Biases
Potential biases may arise from the retrospective design and the specific clinical setting of the study.
Limitations
The study's findings may not be generalizable due to the specific patient population and the retrospective nature of the data collection.
Participant Demographics
The cohort comprised 325 NHL patients, with 51.7% male and 52.6% over 60 years old.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI: 0.528–0.750
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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