Cognitive Variability in Adults with and without HIV-Associated Neurocognitive Disorder
Author Information
Author(s): Vance David, Blake Jason, Li Wei, Wheeler Pariya, Collette Christopher, Jacob Alexandra, Kamath Vidyulata, Bene Victor Del
Primary Institution: University of Alabama at Birmingham
Hypothesis
Cognitive intra-individual variability (IIV) is greater in people living with HIV who have HIV-Associated Neurocognitive Disorder (HAND) compared to those without HAND.
Conclusion
Individuals with HAND show greater cognitive variability than those without HAND, and race-related differences in cognitive variability are influenced by education and reading levels.
Supporting Evidence
- Cognitive intra-individual variability is a marker of cognitive control related to neuropathology.
- Prior research indicated increased cognitive IIV in people living with HIV.
- The study found that cognitive IIV was greater in the HAND group compared to the Non-HAND group.
- Race differences in cognitive IIV were significant but explained by education and reading ability.
Takeaway
This study found that people with a specific type of brain issue related to HIV have more ups and downs in their thinking skills compared to those without that issue.
Methodology
Participants completed a neuropsychological assessment, and group differences were analyzed using analysis of covariance.
Potential Biases
Potential biases may arise from the demographic homogeneity of the sample.
Limitations
The study may be limited by the sample size and the specific demographic focus on older adults in the Deep South.
Participant Demographics
The study included older adults living with HIV, with a focus on racial differences.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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