Evaluating Biomarkers in Cutaneous Leishmaniasis
Author Information
Author(s): Canpolat-Erkan Revsa Evin, Tekin Recep, Sula Bilal
Primary Institution: Dicle University
Hypothesis
This study aims to investigate the association between serum levels of specific biomarkers, such as presepsin, apelin, and irisin, and the clinical features of cutaneous leishmaniasis.
Conclusion
Measuring presepsin levels in patients with cutaneous leishmaniasis may help in assessing disease progression and response to treatment.
Supporting Evidence
- Presepsin levels were significantly elevated in the patient group compared to the controls.
- A negative correlation was identified between presepsin levels and the number and size of lesions.
- Presepsin may serve as a prognostic marker in cutaneous leishmaniasis.
Takeaway
This study looked at how certain proteins in the blood relate to skin infections caused by parasites. It found that one protein, presepsin, is higher in people with the infection.
Methodology
A single-centre, prospective cohort study comparing serum biomarker levels in 30 patients with cutaneous leishmaniasis and 30 healthy controls.
Limitations
The study had a small sample size and was conducted at a single centre.
Participant Demographics
Among the 30 patients, 16 were male and 14 were female, with a mean age of 46 years.
Statistical Information
P-Value
0.000
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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