Prognostic Value of PET/CT in High Risk Melanoma
Author Information
Author(s): Essler Markus, Link Anna, Belloni Benedetta, Mirceva Vesna, Souvatzoglou Michael, Thaler Markus, Haller Bernhard, Hein Ruediger, Krause Bernd J.
Primary Institution: Technische Universität München
Hypothesis
To assess the prognostic value of FDG PET/CT compared to the tumor markers S100B and MIA in patients with high risk melanoma.
Conclusion
PET/CT has a higher prognostic power in the assessment of cancer-associated mortality in melanoma patients compared with S100 and MIA.
Supporting Evidence
- FDG PET/CT was positive in 62 patients out of 125.
- Patients with elevated S100B or MIA values showed a significantly higher risk of melanoma associated death.
- The negative predictive value for PET/CT was 96.8%.
Takeaway
This study found that a special type of scan called PET/CT is better at predicting how likely melanoma patients are to survive compared to other tests.
Methodology
Retrospective study analyzing 125 patients with high risk melanoma who underwent FDG PET/CT for re-staging.
Potential Biases
Potential bias due to the retrospective nature and reliance on existing medical records.
Limitations
The study is retrospective and may have selection bias.
Participant Demographics
Mean age of participants was 58.8 years, with 46.4% female and 53.6% male.
Statistical Information
P-Value
p<0.001
Confidence Interval
95% CI, 89.1% to 99.1%
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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