Increased PADI4 Expression in Malignant Tumors
Author Information
Author(s): Chang Xiaotian, Han Jinxiang, Pang Li, Zhao Yan, Yang Yi, Shen Zhonglin
Primary Institution: Key Laboratory for Bio-drugs of Ministry of Health, Research Center For Medicinal Biotechnology, Shandong Academy of Medical Sciences
Hypothesis
Does increased PADI4 expression correlate with malignant tumors?
Conclusion
PADI4 expression is increased in the blood and tissues of many malignant tumors, which may help in understanding tumorigenesis.
Supporting Evidence
- PADI4 was significantly expressed in various malignancies including breast and lung cancers.
- Immunohistochemistry showed PADI4 expression in over 40% of malignant lymphoma cells.
- ELISA detected increased PADI4 levels in the blood of patients with malignant tumors compared to benign tumors.
Takeaway
The study found that a protein called PADI4 is found in higher amounts in cancer patients compared to healthy people, which might help doctors understand cancer better.
Methodology
The study used immunohistochemistry, real-time PCR, western blot, and ELISA to analyze PADI4 expression in tumor and non-tumor tissues.
Potential Biases
Potential bias in sample selection and the interpretation of immunohistochemical results.
Limitations
The study may not account for all benign tumors and non-tumor conditions that could affect PADI4 levels.
Participant Demographics
Patients with various malignant tumors and controls including healthy individuals and those with benign tumors.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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