Chemoprevention of intestinal tumorigenesis by nabumetone: induction of apoptosis and Bcl-2 downregulation
2001
Nabumetone and Colon Cancer Prevention
publication
Evidence: moderate
Author Information
Author(s): Roy H K, Karoski W J, Ratashak A, Smyrk T C
Primary Institution: University of Nebraska Medical Center/Eppley Cancer Institute
Hypothesis
Does nabumetone induce apoptosis and downregulate Bcl-2 to prevent intestinal tumorigenesis?
Conclusion
Nabumetone effectively suppresses intestinal tumorigenesis and induces apoptosis in colon cancer cells.
Supporting Evidence
- Nabumetone downregulated the anti-apoptotic protein Bcl-2.
- Nabumetone induced apoptosis in HT-29 colon cancer cells.
- The study suggests a potential mechanism for colon cancer chemoprevention.
Takeaway
Nabumetone, a pain reliever, can help stop cancer from growing in the intestines by making cancer cells die.
Methodology
Treatment of MIN mice with nabumetone was used to assess its effects on intestinal tumorigenesis.
Participant Demographics
MIN mice were used in the study.
Digital Object Identifier (DOI)
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