The Origin of 'Frozen' Virus Genome Sequences
Author Information
Author(s): Massey Steven E.
Primary Institution: Biology Department, University of Puerto Rico-Rio Piedras
Hypothesis
The study investigates the origin of 'frozen' virus genome sequences and their connection to escapes from research facilities.
Conclusion
The study suggests that 'frozen' virus genome sequences likely originate from laboratory escapes, indicating a need for improved biosafety measures.
Supporting Evidence
- 'Frozen' virus genome sequences show low divergence from historical strains.
- The 1977 H1N1 strain re-emerged after being stored for decades.
- Venezuelan equine encephalitis virus from 1995 showed high identity to earlier strains.
- Enterovirus 71 strains from a 2007 outbreak were closely related to a 1970 strain.
- Poliovirus isolated in 2014 was nearly identical to a strain from 1950.
Takeaway
Scientists found that some viruses that seem to have been frozen in time actually came from labs, and we need to be more careful to prevent these viruses from escaping.
Methodology
The study reviews known 'frozen' virus genome sequences and analyzes their historical context and potential laboratory origins.
Limitations
The study relies on existing data and may not account for all possible sources of 'frozen' sequences.
Digital Object Identifier (DOI)
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