Anlotinib combined with tislelizumab in the treatment of primary small cell neuroendocrine carcinoma of the prostate: a case report and literature review
2024

Combination Treatment for Rare Prostate Cancer

Sample size: 1 publication Evidence: low

Author Information

Author(s): Fei Xin, Zheng Zhong, Zhao Zhen-ya, Ren Da-wei, Wang Su-ying, Ye Shi-jie, Liang Lin-chun, Li Da, Jia Xiao-long, Ma Qi

Primary Institution: Ningbo University, Ningbo, China

Hypothesis

Can anlotinib combined with tislelizumab improve outcomes in patients with primary small cell neuroendocrine carcinoma of the prostate?

Conclusion

The combination of anlotinib and tislelizumab led to significant tumor shrinkage and prolonged progression-free survival in a patient with advanced prostate cancer.

Supporting Evidence

  • The patient had a progression-free survival time of more than 22 months after treatment.
  • Imaging showed significant improvement after the combination therapy.
  • The patient experienced no significant side effects during the treatment.

Takeaway

A patient with a rare type of prostate cancer was treated with two drugs together, and it helped him feel better and live longer than expected.

Methodology

The patient received anlotinib and tislelizumab after failing standard chemotherapy, with treatment cycles every three weeks.

Limitations

The study is based on a single case report, limiting generalizability.

Participant Demographics

An elderly male patient with advanced primary small cell neuroendocrine carcinoma of the prostate.

Digital Object Identifier (DOI)

10.3389/fimmu.2024.1510069

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