Genome Sequencing of Two Propionibacterium acnes Phages
Author Information
Author(s): Lood Rolf, Collin Mattias
Primary Institution: Lund University
Hypothesis
Do the genomes of inducible P. acnes phages PAD20 and PAS50 display significant similarities and differences compared to previously sequenced phages?
Conclusion
The P. acnes phages PAD20 and PAS50 share a high degree of homology with other P. acnes phages but exhibit a pseudolysogenic life cycle.
Supporting Evidence
- The genomes of PAD20 and PAS50 are 29,074 and 29,017 bp, respectively.
- The phages are inducible but can be cured from bacteria by serial colony isolations.
- Phylogenetic analysis suggests that P. acnes phages represent a new lineage of Siphoviruses.
Takeaway
Scientists studied two viruses that infect a skin bacterium and found they are very similar to each other but not to other viruses. They also learned these viruses don't live inside the bacteria like some others do.
Methodology
The genomes of two inducible P. acnes phages were sequenced and compared to a previously sequenced phage.
Limitations
The study does not identify any putative virulence factors in the phage genomes.
Digital Object Identifier (DOI)
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