FAT10, a gene up-regulated in various cancers, is cell-cycle regulated
2006
FAT10 Gene Regulation During Cell Cycle
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): Lim Chuan-Bian, Zhang Dongwei, Lee Caroline GL
Primary Institution: National Cancer Center, Singapore
Hypothesis
Is the expression of the FAT10 gene regulated in a cell-cycle dependent manner?
Conclusion
FAT10 expression is regulated during the cell cycle.
Supporting Evidence
- FAT10 expression peaks during the S phase of the cell cycle.
- High FAT10 levels can lead to chromosome instability.
- FAT10 expression is negatively regulated by p53.
Takeaway
The FAT10 gene helps control how cells divide, and its levels change depending on the cell cycle stage.
Methodology
HCT116 cells were synchronized at different cell cycle stages, and FAT10 expression was measured using Western blot and RT-PCR.
Participant Demographics
HCT116 human colon carcinoma cells
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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