Early Apoptosis of Blood Monocytes in Septic Patients
Author Information
Author(s): Giamarellos-Bourboulis Evangelos J, Routsi Christina, Plachouras Diamantis, Markaki Vassiliki, Raftogiannis Maria, Zervakis Dimitrios, Koussoulas Vassilios, Orfanos Stylianos, Kotanidou Anastasia, Armaganidis Apostolos, Roussos Charis, Giamarellou Helen
Primary Institution: University of Athens, Medical School, Greece
Hypothesis
Is early apoptosis of blood monocytes a mechanism of protection in septic shock?
Conclusion
Early apoptosis of monocytes is linked to a better outcome in septic patients.
Supporting Evidence
- Patients with monocyte apoptosis ≤50% had a mortality rate of 49.12%.
- Patients with monocyte apoptosis >50% had a mortality rate of 15.15%.
- Kaplan-Meier analysis showed a survival benefit in patients with monocyte apoptosis >50%.
Takeaway
When some blood cells called monocytes die early in septic patients, it can actually help them survive better.
Methodology
Blood monocytes were isolated from 90 patients with septic syndrome and analyzed for apoptosis and cytokine production.
Limitations
The study's findings should be verified in a larger population and initial antimicrobial treatment may have affected results.
Participant Demographics
Patients were aged over 18, intubated for at least 48 hours, and had ventilator-associated pneumonia.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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