Effects of Black Chokeberry Extracts on Mice Aorta
Author Information
Author(s): Buda Valentina, Sturza Adrian, Minda Daliana, Diaconeasa Zorița, Iuhas Cristian, Bădescu Bianca, Dehelean Cristina-Adriana, Danciu Corina, Muntean Mirela-Danina, Lighezan Rodica, Dănilă Maria-Daniela, Djuric Dragan M.
Primary Institution: Victor Babeș University of Medicine and Pharmacy of Timișoara, Romania
Hypothesis
The study aims to evaluate the effects of black chokeberry extracts on oxidative stress and vascular function in mice aortic rings.
Conclusion
Black chokeberry extracts showed a concentration-dependent vasculo-protective effect by reducing oxidative stress and improving endothelial function in mice aortas.
Supporting Evidence
- Both types of extracts decreased H2O2 and superoxide levels in a concentration-dependent manner.
- At 100 µg/mL, both extracts significantly improved vascular relaxation in all stimulated aortic rings.
- The FrozAr extract was rich in anthocyanins, while the DryAr extract was rich in flavonols.
- Both extracts exhibited a significant catalase-like scavenger effect on H2O2.
Takeaway
Black chokeberry extracts can help protect blood vessels by reducing harmful substances and making them work better.
Methodology
The study involved incubating mice aortic rings with black chokeberry extracts and assessing oxidative stress and vascular reactivity.
Limitations
Only male mice were used, which may limit the generalizability of the findings.
Participant Demographics
Young male mice (BALB/c strain, 4 weeks, 25 g)
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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