Enhanced dissolution rate of felodipine using spherical agglomeration with Inutec SP1 by quasi emulsion solvent diffusion method
2009
Improving Felodipine Dissolution with Spherical Agglomeration
Sample size: 3
publication
Evidence: moderate
Author Information
Author(s): Tapas A.R., Kawtikwar P.S., Sakarkar D.M.
Primary Institution: Sudhakarrao Naik Institute of Pharmacy
Hypothesis
Can the dissolution rate of felodipine be improved using spherical agglomeration with Inutec SP1?
Conclusion
The study successfully enhanced the dissolution rate of felodipine by using spherical agglomeration with Inutec SP1.
Supporting Evidence
- The dissolution efficiency of felodipine increased to about 4-fold in phosphate buffer after using spherical agglomeration.
- FTIR and DSC results showed no significant change in the drug after the crystallization process.
- PXRD studies indicated a minor reduction in the height of peaks, suggesting changes in crystallinity.
Takeaway
The researchers found a way to make a medicine dissolve better in water, which helps it work faster in the body.
Methodology
Spherical agglomerates were prepared using a quasi emulsion solvent diffusion method with acetone, dichloromethane, and water.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
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