β,β-Difluoro Peroxides as Fluorinated C2-Building Blocks for the Construction of Functionalized Indolizines
2024
New Method for Making Functionalized Indolizines
publication
Evidence: moderate
Author Information
Author(s): Ma Yangyang, Zhang Hua, Du Xiaoxiao, Fang Shurui, Yin Kexin, Du Gangfeng, Tian Zhengshan, Zhou Zhonghao
Primary Institution: Pingdingshan University
Hypothesis
Can β,β-difluoro peroxides be used as effective building blocks for synthesizing functionalized indolizines?
Conclusion
A new method using β,β-difluoro peroxides allows for the efficient synthesis of a variety of functionalized indolizines.
Supporting Evidence
- The method allows for the preparation of multisubstituted indolizines in moderate to good yields.
- Various functional groups were tolerated in the synthesis process.
- The use of β,β-difluoro peroxides provides a straightforward and regioselective route.
Takeaway
Scientists found a new way to make special chemical compounds called indolizines using a simple method with certain building blocks.
Methodology
The study involved the oxidative [3+2] annulation of β,β-difluoro peroxides with pyridinium ylides under base-mediated conditions.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website