TISs-ST: A Web Server for Evaluating Translation Initiation Sites
Author Information
Author(s): Vicentini Renato, Menossi Marcelo
Primary Institution: State University of Campinas
Hypothesis
The study investigates the usage of alternative translation initiation sites for the synthesis of new protein variants that might have different functions.
Conclusion
The TISs-ST web server provides tools for evaluating alternative translation initiation sites and predicting signal peptides.
Supporting Evidence
- The TISs-ST web server is freely available to both academic and commercial users.
- TISs-ST provides analytical and visualization tools for evaluating the periodic frequency and consensus pattern of sequences.
- The program can identify signal peptides from predicted proteins using the PrediSi software.
Takeaway
This study created a website that helps scientists find different starting points for making proteins, which can lead to proteins with different jobs in the cell.
Methodology
The TISs-ST web server uses user-specified sequences and a position weight matrix model to analyze translation initiation sites.
Limitations
The target prediction is limited to signal peptides, and there are few tools available for protein sub-cellular localization prediction.
Digital Object Identifier (DOI)
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