Identifying Early Breast Cancer with p43-Positive Lymphocytes
Author Information
Author(s): Auerbach L, Hellan M, Stierer M, Rosen A C, Ausch C, Obwegeser R, Kubista E, Wolf G, Rosen H R
Primary Institution: Departments of Gynaecology and Obstetrics and Diagnostic Radiology, and Clinic for Blood Group Serology, Division of Special Gynecology, Vienna, Austria
Hypothesis
Can the expression of p43-positive lymphocytes serve as a reliable marker for early-stage breast cancer?
Conclusion
The presence of p43-positive lymphocytes in peripheral blood can help identify early breast cancer and reduce unnecessary invasive procedures.
Supporting Evidence
- Patients with early breast cancer had significantly higher p43-positive cell values than those with benign lumps or controls.
- At a cut-off level of 2% p43-positive cells, sensitivity was 91.7% and specificity was 89.3% for breast cancer detection.
Takeaway
Doctors can use a special test to find certain cells in the blood that help them know if someone has early breast cancer, which can make things easier for patients.
Methodology
The study evaluated p43-positive lymphocytes using flow cytometry in women with non-palpable mammographic findings.
Participant Demographics
76 women with controversial, non-palpable mammographic findings.
Statistical Information
P-Value
P < 0.0001
Confidence Interval
0.98–19.4
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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