Big Endothelin-1 Levels and Esophageal Cancer
Author Information
Author(s): Jiao Wenjie, Xu Jing, Zheng Jinsheng, Shen Yi, Lin Lesheng, Li Jian
Primary Institution: Peking University First Hospital
Hypothesis
Can plasma big ET-1 levels predict tumor recurrence and survival in esophageal squamous cell carcinoma patients?
Conclusion
Higher plasma big ET-1 levels in ESCC patients may indicate worse survival and higher risk of tumor recurrence.
Supporting Evidence
- Preoperative plasma big ET-1 levels were significantly higher in ESCC patients compared to controls.
- Patients with postoperative recurrence had significantly higher plasma big ET-1 levels.
- The survival rate was significantly lower for patients with higher plasma big ET-1 concentrations.
Takeaway
Doctors found that higher levels of a substance called big ET-1 in the blood can mean that esophageal cancer might come back or be more serious.
Methodology
Plasma big ET-1 levels were measured in 108 ESCC patients before and after surgery using ELISA.
Limitations
The study excluded patients with certain co-morbid conditions and those who had prior chemotherapy or radiotherapy.
Participant Demographics
78 men and 30 women with a median age of 64.5 years.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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