p53 Protein and Ewing's Sarcoma Prognosis
Author Information
Author(s): Abudu A, Mangham D C, Reynolds G M, Pynsent P B, Tillman R M, Carter S R, Grimer R J
Primary Institution: Royal Orthopaedic Hospital Oncology Service
Hypothesis
Does overexpression of p53 protein in Ewing's sarcoma relate to tumor stage, response, and prognosis?
Conclusion
Overexpression of p53 protein is linked to a poorer prognosis in patients with Ewing's sarcoma of bone.
Supporting Evidence
- Overexpression of p53 protein was found in 14% of patients.
- Patients with p53 overexpression had a 5-year relapse-free survival of only 20%.
Takeaway
If a patient with Ewing's sarcoma has a lot of p53 protein, they might not do as well as others who don't have as much.
Methodology
Biopsy tissues of patients were examined immunohistochemically to assess p53 protein levels.
Limitations
The study only included patients treated between 1983 and 1993, which may limit the applicability of the findings to current treatment protocols.
Participant Demographics
Mean age at diagnosis was 17 years, with a range from 6 to 36 years.
Statistical Information
P-Value
0.01
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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