BRIP1 Variants and Breast Cancer Risk
Author Information
Author(s): Frank Bernd, Hemminki Kari, Meindl Alfons, Wappenschmidt Barbara, Sutter Christian, Kiechle Marion, Bugert Peter, Schmutzler Rita K, Bartram Claus R, Burwinkel Barbara
Primary Institution: German Cancer Research Center, DKFZ, Heidelberg, Germany
Hypothesis
Do BRIP1 variants -64G>A and Pro919Ser affect familial breast cancer risk?
Conclusion
The study found no effect of the BRIP1 variants on the risk of familial breast cancer.
Supporting Evidence
- The study included a large sample size of 1283 participants.
- No significant differences in genotype frequencies were observed between breast cancer cases and controls.
- The study cohort was homogeneous, comprising women selected for familial breast cancer.
Takeaway
The study looked at two gene changes to see if they make breast cancer more likely in families, but they didn't find any link.
Methodology
The study analyzed BRIP1 variants in 571 breast cancer patients and 712 controls using TaqMan allelic discrimination.
Limitations
The study did not test for gene-environment interactions due to lack of data on known risk factors.
Participant Demographics
571 unrelated German female index cases aged 19 to 87 years, and 712 healthy female controls aged 26 to 68 years.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website