Genetic Variants Linked to Type 2 Diabetes in Young Indian Professionals
Author Information
Author(s): Husami Shah Fahad, Kaur Tavleen, Gupta Love, Rastogi Garima, Singh Lakhvinder, Meena Pooja, Sharma Indu, Singh Hemender, Sharma Varun
Primary Institution: Unlock Wellness Pvt. Ltd.
Hypothesis
The study aims to find genetic variants associated with T2D predisposition in young Indian professionals.
Conclusion
The study identified 42 genetic variants associated with an increased risk of type 2 diabetes among young corporate professionals in India.
Supporting Evidence
- 42 genetic variants were found to be significantly associated with T2D risk.
- Three missense variants were identified that may alter protein structure.
- Genetic predisposition to T2D is influenced by environmental factors like stress and lifestyle.
Takeaway
This study looked at young workers in India to see if their genes make them more likely to get diabetes, and they found some important clues.
Methodology
The study involved screening 680 young professionals for 2658 genetic variants using advanced genomic techniques and statistical analysis.
Potential Biases
Potential bias may arise from the specific demographic of corporate professionals and their lifestyle factors.
Limitations
The study is limited to young professionals in the corporate sector and may not be generalizable to other populations.
Participant Demographics
The study included 284 T2D cases (222 males and 62 females) aged 24 to 50 years and 396 controls (304 males and 92 females) aged 25 to 55 years.
Statistical Information
P-Value
p<0.000028
Statistical Significance
p<0.000028
Digital Object Identifier (DOI)
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