Effects of Platelet-Rich Fibrin on Bone Healing Around Implants in Rabbits
Author Information
Author(s): Grossi-Oliveira Gustavo Augusto, Dallazen Eduardo, Asbi Thabet, Fonseca-Santos João Matheus, Ribeiro-Júnior Paulo Domingos, Shibli Jamil A., Massari Grecco Cinthya, Magro-Filho Osvaldo, Mourão Carlos Fernando, Haim Doron, Mayer Yaniv, Faverani Leonardo P.
Primary Institution: Department of Diagnosis and Surgery, Division of Oral and Maxillofacial Surgery and Implantology, School of Dentistry, São Paulo State University (UNESP), Araçatuba, Brazil
Hypothesis
This study aimed to explore the effect of platelet-rich fibrin on bone healing around implants placed in elevated sinus cavities.
Conclusion
Combining hydroxyapatite with platelet-rich fibrin promotes better osseointegration around implants placed in maxillary sinus augmentation.
Supporting Evidence
- Significant increases in bone-to-implant contact (BIC) and bone area fraction occupancy (BAFO) values were observed at 40 days compared to 14 days.
- At day 14, the HA+PRF group had higher BIC than the control and PRF alone groups.
- At 40 days, HA+PRF maintained the highest BIC across all groups.
Takeaway
The study found that using a special blood product called platelet-rich fibrin helps bones heal better around dental implants in rabbits.
Methodology
Forty New Zealand albino rabbits were divided into groups and underwent sinus augmentation with different materials, followed by histological analysis.
Limitations
The study's limitations include the accelerated healing rate in rabbits compared to humans and the focus on only the central portion of the implant.
Participant Demographics
Forty albino New Zealand rabbits, approximately 5–6 months old, weighing 3–4 kg.
Statistical Information
P-Value
p<0.001
Confidence Interval
95%
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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