Comparative analysis of septic injury-inducible genes in phylogenetically distant model organisms of regeneration and stem cell research, the planarian Schmidtea mediterranea and the cnidarian Hydra vulgaris
2008
Comparative Analysis of Immune-Inducible Genes in Planarians and Cnidarians
Sample size: 288
publication
Evidence: moderate
Author Information
Author(s): Boran Altincicek, Andreas Vilcinskas
Primary Institution: Justus-Liebig-University of Giessen
Hypothesis
Regeneration processes may be linked to or at least accompanied by innate immune responses.
Conclusion
The study identified numerous immune-inducible genes in Hydra and Schmidtea that show a similar distribution corresponding to their physiological roles.
Supporting Evidence
- 27 immune-inducible genes were identified in Schmidtea and 35 in Hydra.
- Identified genes are involved in signaling, stress responses, and antimicrobial defense.
- Both organisms share similar physiological roles despite diverging over 500 million years ago.
Takeaway
Scientists studied two types of animals that can regrow body parts to see how their immune systems react to injuries, finding many genes that help them heal.
Methodology
The suppression subtractive hybridization technique was used to identify differentially expressed genes in response to septic injury.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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