Survivin Expression in Oesophageal Cancer
Author Information
Author(s): Grabowski P, Kühnel T, Mühr-Wilkenshoff F, Heine B, Stein H, Höpfner M, Germer C T, Scherübl H
Primary Institution: Benjamin Franklin Clinics, FU Berlin
Hypothesis
The study investigates the prognostic relevance of nuclear survivin expression in oesophageal squamous cell carcinoma.
Conclusion
Nuclear survivin expression is associated with a poorer prognosis in patients with oesophageal squamous cell carcinoma.
Supporting Evidence
- 80% of oesophageal squamous cell carcinoma tumors showed positive nuclear staining for survivin.
- Patients with nuclear survivin expression had a mean survival of 28 months compared to 108 months for those without.
- Nuclear survivin expression was significantly associated with lymph node metastasis.
Takeaway
This study found that if a certain protein called survivin is present in the nucleus of cancer cells, it usually means the cancer is more aggressive and the patient may not live as long.
Methodology
The study analyzed the protein expression of survivin in oesophageal squamous cell carcinoma patients using immunohistochemistry and assessed its correlation with clinical outcomes.
Participant Demographics
The study included 84 patients who underwent oesophagectomy, with a median age of 56.8 years.
Statistical Information
P-Value
0.0028
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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