Anti-Urolithiatic Activity of Pergularia daemia Extract in Rats
Author Information
Author(s): Vyas BA, Vyas RB, Joshi SV, Santani DD
Primary Institution: Maliba Pharmacy College, Gopal Vidyanagar, Tarsadi, Gujarat, India
Hypothesis
The study investigates the antiurolithiatic properties of the whole-plant hydroalcoholic extract of Pergularia daemia in rats.
Conclusion
The extract significantly reduced urinary excretion and kidney retention levels of stone-forming constituents, affirming its effectiveness against urinary pathologies.
Supporting Evidence
- The extract significantly lowered urinary excretion of oxalate, calcium, and phosphate.
- High serum levels of urea nitrogen, creatinine, and uric acid were significantly reduced by the extract.
- The extract exhibited significant diuretic activity, increasing total urine volume and electrolyte concentration.
Takeaway
This study shows that a plant extract can help prevent kidney stones in rats by reducing harmful substances in urine.
Methodology
Wistar rats were used to test the extract's effects on ethylene glycol-induced urolithiasis over 28 days.
Limitations
The study was conducted only in rats, and the effects in humans are not yet established.
Participant Demographics
Wistar rats (200-250 g) and Swiss albino mice of either sex were used.
Statistical Information
P-Value
<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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