Effects of Lycopene and Fish Oil on Prostate Cancer Gene Expression
Author Information
Author(s): Magbanua Mark Jesus M., Roy Ritu, Sosa Eduardo V., Weinberg Vivian, Federman Scott, Mattie Michael D., Hughes-Fulford Millie, Simko Jeff, Shinohara Katsuto, Haqq Christopher M., Carroll Peter R., Chan June M.
Primary Institution: University of California San Francisco
Hypothesis
How do lycopene and fish oil supplementation affect gene expression in men with prostate cancer?
Conclusion
The study found no significant individual genes associated with dietary intake and supplementation of lycopene and fish oil, but identified candidate pathways that may be modulated by these micronutrients.
Supporting Evidence
- Exploratory pathway analyses revealed modulation of androgen and estrogen metabolism in men who consumed more fish and tomato.
- Fish oil supplementation showed modulation of arachidonic acid metabolism.
- Nrf2-mediated oxidative stress response was observed in both supplement arms compared to placebo.
Takeaway
This study looked at how certain foods might change the way our genes work in men with prostate cancer, but didn't find clear evidence that they do.
Methodology
Eighty-four men with low-risk prostate cancer were randomly assigned to receive either lycopene, fish oil, or placebo for three months, and gene expression was analyzed using cDNA microarray.
Potential Biases
Potential variability in individual diets and the inherent noise in microarray technology may have masked subtle effects.
Limitations
The study had a small sample size and the intervention period of three months may have been too short to detect significant changes.
Participant Demographics
Men with low burden prostate cancer, histologically documented prostate adenocarcinoma, and specific eligibility criteria.
Statistical Information
P-Value
p=0.001
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website