Predicting Response to Cardiac Resynchronization Therapy with 3D Speckle Tracking
Author Information
Author(s): Tatsumi Kazuhiro, Tanaka Hidekazu, Tsuji Takayuki, Kaneko Akihiro, Ryo Keiko, Yamawaki Kohei, Omar Alaa MS, Fukuda Yuko, Norisada Kazuko, Matsumoto Kensuke, Onishi Tetsuari, Yoshida Akihiro, Kawai Hiroya, Hirata Ken-ichi
Primary Institution: Kobe University Graduate School of Medicine
Hypothesis
Strain dyssynchrony index using area tracking (ASDI) can quantify dyssynchrony and predict response to cardiac resynchronization therapy (CRT).
Conclusion
ASDI can predict responders and LV reverse remodeling following CRT.
Supporting Evidence
- ASDI ≥ 3.8% was the best predictor of response to CRT with a sensitivity of 78% and specificity of 100%.
- Baseline ASDI correlated with reduction of LV end-systolic volume following CRT (r = 0.80, p < 0.001).
- Response to CRT was observed in nine patients (64%).
- ASDI was associated with the highest incidence of echocardiographic improvement after CRT with a response rate of 100%.
Takeaway
Doctors can use a special measurement called ASDI to see if heart failure patients will get better after a treatment called CRT.
Methodology
Echocardiography was performed before and 6 months after CRT on 14 heart failure patients, and ASDI was calculated using 3-D speckle tracking imaging.
Potential Biases
The study population was heterogeneous, which may affect the generalizability of the results.
Limitations
The study had a small sample size and was conducted at a single center.
Participant Demographics
Mean age was 70 ± 9 years; 12 males and 2 females; 36% had ischemic cardiomyopathy.
Statistical Information
P-Value
p<0.001
Confidence Interval
0.67-0.99
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website