Methyl 1-(2,6-difluorobenzyl)-1H-1,2,3-triazole-4-carboxylate
2011
Study of a Chemical Compound for Drug Development
publication
Evidence: moderate
Author Information
Author(s): Dong Su-Lan, Cheng Xiao-Chun
Primary Institution: Huaiyin Institute of Technology
Hypothesis
The title compound is an important organic intermediate useful in preparing the anti-convulsant drug rufinamide.
Conclusion
The synthesized compound exhibits a stable crystal structure with specific intermolecular interactions.
Supporting Evidence
- The compound is an intermediate in the preparation of the anti-convulsant drug rufinamide.
- The crystal structure is stabilized by intermolecular hydrogen bonds.
- The dihedral angle between the triazole ring and the benzene ring is 77.3°.
Takeaway
Scientists made a special chemical that can help create a medicine for seizures. They looked at how the molecules fit together.
Methodology
The compound was synthesized through a reaction of 2,6-fluorobenzyl azide and methyl propiolate, followed by crystallization.
Digital Object Identifier (DOI)
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