Schistosomiasis Increases Endothelial Cell-Leukocyte Interaction
Author Information
Author(s): Oliveira Suellen D. S., Quintas Luis E. M., Amaral Luciana S., Noël François, Farsky Sandra H., Silva Claudia L. M.
Primary Institution: Federal Universidade of Rio de Janeiro, Brazil
Hypothesis
Schistosomiasis affects endothelial cell function and increases leukocyte adhesion.
Conclusion
Schistosomiasis increases vascular permeability and endothelial cell-leukocyte interaction, partly due to reduced eNOS expression.
Supporting Evidence
- Leukocyte adhesion to endothelial cells was six times higher in infected mice compared to controls.
- Endothelial cells from infected mice showed reduced eNOS expression.
- NO donation reduced leukocyte adhesion in both infected and control groups.
Takeaway
When mice get schistosomiasis, their blood vessel cells become stickier, making it easier for white blood cells to attach and cause inflammation.
Methodology
The study used infected and control mice to assess leukocyte adhesion and vascular permeability through in vivo and in vitro experiments.
Limitations
The specific mediators responsible for reduced eNOS expression were not identified.
Participant Demographics
Male Swiss mice aged 75 to 90 days.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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