Lsm1 and Prostate Cancer Progression
Author Information
Author(s): Takahashi S, Suzuki S, Inaguma S, Cho Y-M, Ikeda Y, Hayashi N, Inoue T, Sugimura Y, Nishiyama N, Fujita T, Ushijima T, Shirai T
Primary Institution: Nagoya City University Medical School
Hypothesis
Is Lsm1 down-regulation involved in the progression of human prostate cancer?
Conclusion
Lsm1 down-regulation is significantly associated with prostate cancer progression and metastasis.
Supporting Evidence
- Lsm1 was found to be down-regulated in advanced prostate cancers.
- Transfectants of Lsm1 showed reduced invasive potential in assays.
- Allelic loss in the Lsm1 region was frequent in refractory cancers.
Takeaway
This study found that a gene called Lsm1, which is usually lower in prostate cancer, helps control how aggressive the cancer can be.
Methodology
The study used cDNA-representational difference analysis to identify differentially expressed genes in prostate cancer.
Potential Biases
Potential bias due to the small number of samples and the nature of the autopsy cases.
Limitations
The sample size was small and RNA quality from refractory cancers was problematic due to autopsy sampling.
Participant Demographics
Included patients with localized and refractory prostate cancers, with no prior chemotherapy or hormonal therapy.
Statistical Information
P-Value
p<0.001
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website