Dopamine and Cutaneous Wound Healing
Author Information
Author(s): Shome Saurav, Rana Tapasi, Ganguly Subhalakshmi, Basu Biswarup, Chaki Choudhury Sandipan, Sarkar Chandrani, Chakroborty Debanjan, Dasgupta Partha Sarathi, Basu Sujit
Primary Institution: Chittaranjan National Cancer Institute, Kolkata, India; Ohio State University, Columbus, Ohio, United States of America
Hypothesis
Dopamine may have a role in the neovascularization of dermal wound tissues and subsequently in the process of wound healing.
Conclusion
Treatment with a specific D2 dopamine receptor antagonist significantly accelerates the process of full thickness normal dermal wound healing in mice by inducing angiogenesis in wound tissues.
Supporting Evidence
- Treatment with eticlopride significantly improved the rate of wound healing in normal Swiss mice.
- Wound closure was 53.4% in treated groups versus 25.5% in control groups on day 5.
- Microvessel density was significantly higher in eticlopride treated groups compared to controls.
Takeaway
Dopamine usually slows down healing, but using a special medicine can help wounds heal faster by making new blood vessels.
Methodology
The study used a murine model of full thickness dermal wound and treated mice with a D2 dopamine receptor antagonist to evaluate wound healing.
Participant Demographics
Normal Swiss mice, 4-6 weeks old, weighing 22-25 g.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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