Metronidazole Resistance in Bacteroides fragilis in India
Author Information
Author(s): Rama Chaudhry, Purva Mathur, Benu Dhawan, Lalit Kumar
Primary Institution: All India Institute of Medical Sciences, New Delhi, India
Hypothesis
What is the incidence of metronidazole resistance in Bacteroides fragilis isolates in India?
Conclusion
The first metronidazole-resistant strain of Bacteroides fragilis was identified in India, highlighting a potential increase in resistance rates.
Supporting Evidence
- Bacteroides fragilis is the most commonly isolated anaerobic pathogen in humans.
- Metronidazole has been the drug of choice for treating Bacteroides infections for 40 years.
- The isolate of B. fragilis was resistant to metronidazole with a MIC of 256 g/mL.
- Antimicrobial resistance in anaerobes varies by location and hospital.
Takeaway
Doctors found a type of bacteria that usually gets treated with a medicine called metronidazole is now resistant to it, which is a big problem for treating infections.
Methodology
The study involved isolating bacteria from a patient and testing their resistance to metronidazole and other antibiotics.
Limitations
The true incidence of metronidazole resistance may be underestimated due to lack of routine testing in many laboratories.
Participant Demographics
A 34-year-old man with myelodysplastic syndrome.
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