Capillary Leak Syndrome Induced by Interleukin-11 in Liver Cancer Patients
Author Information
Author(s): Kai-Feng Wang, Hong-Ming Pan, Hai-Zhou Lou, Li-Rong Shen, Xi-Yan Zhu
Primary Institution: Department of Oncology, Sir Run Run Shaw Hospital, Medical School, Zhejiang University
Hypothesis
Can interleukin-11 treatment cause capillary leak syndrome in patients with primary hepatic carcinoma and thrombocytopenia?
Conclusion
Interleukin-11 can induce capillary leak syndrome in liver cancer patients, but they can recover with appropriate treatment.
Supporting Evidence
- Both patients developed capillary leak syndrome after receiving interleukin-11.
- Patient 1 recovered after 19 days of treatment involving fluid resuscitation and blood transfusions.
- Patient 2 improved after two weeks of treatment following the cessation of interleukin-11.
Takeaway
Two patients with liver cancer got very sick after taking a medicine called interleukin-11, but they got better with the right treatment.
Methodology
Case reports of two patients treated with interleukin-11 for thrombocytopenia who developed capillary leak syndrome.
Limitations
Only two cases were reported, limiting the generalizability of the findings.
Participant Demographics
Two male patients, aged 46 and 66, both with primary hepatic carcinoma and thrombocytopenia.
Digital Object Identifier (DOI)
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