Kinome Expression Profiling and Prognosis of Basal Breast Cancers
Author Information
Author(s): Sabatier Renaud, Finetti Pascal, Mamessier Emilie, Raynaud Stéphane, Cervera Nathalie, Lambaudie Eric, Jacquemier Jocelyne, Viens Patrice, Birnbaum Daniel, Bertucci François
Primary Institution: Institut Paoli-Calmettes
Hypothesis
The expression of kinase genes may distinguish good- from poor-prognosis basal tumors.
Conclusion
A prognostic model based on kinome expression can separate basal breast cancers into two subgroups with different prognoses.
Supporting Evidence
- A 28-kinase metagene was identified that correlates with disease-free survival.
- Patients with tumors overexpressing the metagene had a 78% 5-year disease-free survival.
- The immune response was linked to better prognosis in basal breast cancer.
- Multivariate analysis showed the metagene outperformed classical prognostic factors.
Takeaway
This study found that certain genes related to the immune system can help predict how well patients with a specific type of breast cancer will do.
Methodology
DNA microarray-based gene expression and histoclinical data were collected from 2515 early breast cancers, with a focus on a 28-kinase metagene associated with disease-free survival.
Limitations
The study may not account for all variables affecting prognosis, and the sample size for some analyses was limited.
Participant Demographics
{"age":{"≤ 50 years":215,"> 50 years":162},"histological_type":{"ductal":234,"lobular":7,"other":15},"tumor_grade":{"SBR 1":14,"SBR 2-3":479},"ER_status":{"negative":411,"positive":96}}
Statistical Information
P-Value
1.62E-04
Confidence Interval
[0.17-0.68]
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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