MASTERPLAN Study: Improving Treatment for Kidney Patients
Author Information
Author(s): Arjan D. van Zuilen, Ingeborgh van der Tweel, Peter J. Blankestijn, Michiel L. Bots, Marjolijn van Buren, Marc A.G.J. ten Dam, Karin A.H. Kaasjager, Peter JG van de Ven, Gerald Vervoort, Louis-Jean Vleming, Gerry Ligtenberg, Jack F.M. Wetzels
Primary Institution: University Medical Center Utrecht
Hypothesis
A multifactorial approach with the aid of nurse practitioners will reduce cardiovascular risk in patients with chronic kidney disease (CKD).
Conclusion
The MASTERPLAN trial aims to establish the effectiveness of a multifactorial approach in reducing cardiovascular events in patients with mild to moderate renal insufficiency.
Supporting Evidence
- Patients with chronic kidney disease are at a greatly increased risk of developing cardiovascular disease.
- A multifactorial approach has been effective in other high-risk populations.
- Approximately 800 patients will be included in the study.
Takeaway
This study is trying to help kidney patients by using a team of nurses to give them better advice on how to stay healthy and avoid heart problems.
Methodology
A multicenter randomized controlled clinical trial with a 5-year follow-up, including approximately 800 patients with CKD.
Potential Biases
Potential bias due to the inability to blind patients and physicians to the intervention.
Limitations
Blinding is not possible, and all patients receive information about risk factor management, which may improve outcomes in the control group.
Participant Demographics
Patients aged 18 and older with CKD and a creatinine clearance between 20 to 70 ml/min.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website