How Certain Receptors Affect Amyloid Precursor Protein in Alzheimer's Disease
Author Information
Author(s): Cam Judy A, Bu Guojun
Primary Institution: Washington University School of Medicine, St. Louis, Missouri, USA; New York University, New York, USA
Hypothesis
Do members of the low-density lipoprotein receptor family influence the processing of amyloid precursor protein (APP) to amyloid-β (Aβ)?
Conclusion
The study suggests that interactions between low-density lipoprotein receptors and APP can modulate Aβ levels, which may have implications for Alzheimer's disease therapies.
Supporting Evidence
- Alterations in APP processing to favor Aβ production are key events in Alzheimer's disease.
- LRP enhances APP endocytosis and processing to Aβ.
- LRP1B retains APP at the cell surface and decreases its processing to Aβ.
- SorLA/LR11 alters APP trafficking and reduces Aβ levels.
- ApoER2 influences APP processing through interactions with F-spondin.
Takeaway
Some proteins in our body help control how a substance related to Alzheimer's disease is made. Understanding how they work could help us find better treatments.
Methodology
The review summarizes various studies on the interactions between low-density lipoprotein receptors and APP, focusing on their effects on APP trafficking and processing.
Limitations
The review is based on existing studies and may not include all recent findings or experimental data.
Digital Object Identifier (DOI)
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