Noise Amplification in Human Tumor Suppression following Gamma Irradiation
2011
Noise Amplification in Human Tumor Suppression after Gamma Irradiation
publication
Evidence: moderate
Author Information
Author(s): Liu Bo, Yan Shiwei, Gao Xingfa
Primary Institution: Beijing Normal University, Beijing, China
Hypothesis
How does intrinsic noise affect the dynamics of human cancer cells following gamma irradiation?
Conclusion
The study shows that intrinsic noise amplifies the response of cancer cells to gamma irradiation through coherence resonance.
Supporting Evidence
- The study clarifies the effect of intrinsic noise on cancer cell dynamics.
- Coherence resonance was identified as a key mechanism in noise amplification.
- Frequency domain analysis was used to study the underlying mechanisms.
Takeaway
This study found that noise in cancer cells can actually help them respond better to radiation treatment.
Methodology
The study used a microscopical signal-response model and Monte Carlo simulations to analyze the dynamics of p53 and Mdm2 proteins in cancer cells.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website