Spectrophotometric Methods for Measuring Alendronate Sodium
Author Information
Author(s): Raza Asad, Zia-ul-Haq Muhammad
Primary Institution: Bio Fine Pharmaceuticals, University of Karachi
Hypothesis
Can simple and accurate spectrophotometric methods be developed for the determination of alendronate sodium in pharmaceutical forms?
Conclusion
The proposed spectrophotometric methods are simple, sensitive, rapid, and low-cost, providing accurate results for alendronate sodium analysis.
Supporting Evidence
- The methods showed a linear relationship over specific concentration ranges.
- No significant difference was found between the new methods and traditional titrimetric procedures.
- The methods are extraction-free and provide precise results.
Takeaway
This study created easy ways to measure a medicine called alendronate sodium without needing complicated steps, making it faster and cheaper.
Methodology
Two spectrophotometric methods were developed based on charge-transfer complex formation with TCNQ and DDQ, measuring absorbance at 840 nm and 465 nm.
Limitations
The study does not specify limitations, but potential interferences from excipients were tested and found not to affect results significantly.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website