Antimicrobial Drug Use and Resistance in Europe
Author Information
Author(s): van de Sande-Bruinsma Nienke, Grundmann Hajo, Verloo Didier, Tiemersma Edine, Monen Jos, Goossens Herman, Ferech Matus
Primary Institution: National Institute of Public Health and the Environment
Hypothesis
Can the notion that antimicrobial drug use determines resistance be supported by surveillance data at national aggregation levels?
Conclusion
The study found a specific and robust association between antimicrobial drug use and resistance for two major pathogens in Europe.
Supporting Evidence
- Antimicrobial drug use in ambulatory care was analyzed alongside resistance trends for two major pathogens.
- The study found significant differences in antimicrobial use and resistance across 21 European countries.
- Linear regression analysis showed a strong correlation between antimicrobial use and resistance for specific pathogens.
Takeaway
This study looked at how much antibiotics are used in different European countries and how that relates to bacteria becoming resistant to those antibiotics.
Methodology
The study used data from the European Surveillance of Antimicrobial Consumption and the European Antimicrobial Resistance Surveillance System to analyze antimicrobial use and resistance trends.
Potential Biases
Potential biases include differences in hygiene, diagnostic habits, and community infection control across countries.
Limitations
Data at a high aggregation level may not be sensitive enough to reflect subtle changes in the interaction between antimicrobial drug prescribing and resistance.
Participant Demographics
The study included data from 21 European countries.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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