Concerted Solvent Processes for Common Sulfonyl Chloride Precursors used in the Synthesis of Sulfonamide-based Drugs
2008

Solvent Effects on Sulfonyl Chloride Reactions

Sample size: 34 publication Evidence: moderate

Author Information

Author(s): D’Souza Malcolm J., Yaakoubd Lamia, Mlynarski Stacey L., Kevill Dennis N.

Primary Institution: Wesley College

Hypothesis

The study investigates how different solvents affect the solvolysis rates of sulfonyl chlorides.

Conclusion

The specific rates of solvolysis for sulfonyl chlorides can be correlated using the extended Grunwald-Winstein equation, showing robust relationships across various solvents.

Supporting Evidence

  • The study found that a single correlation controls the influence of solvent over the full range of solvent composition.
  • The specific rates of solvolysis were determined in various solvents, including fluoroalcohols.
  • The results showed that the solvolysis of sulfonyl chlorides can be effectively modeled using the extended Grunwald-Winstein equation.

Takeaway

This study looks at how different liquids can change the speed of chemical reactions involving certain compounds called sulfonyl chlorides.

Methodology

The study measured specific rates of solvolysis in various solvents and correlated the data using the extended Grunwald-Winstein equation.

Limitations

The correlation at 45.0 °C had only seven data points, which is less than the recommended number for a two-term correlation.

Statistical Information

P-Value

p<0.05

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.3390/ijms9050914

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