Cyclical Mastalgia and Breast Cancer Risk
Author Information
Author(s): G. Plu-Bureau, J.C. Thalabard, R. Sitruk-Ware, B. Asselain, P. Mauvais-Jarvis
Primary Institution: Institut Curie, Paris, France
Hypothesis
Does cyclical mastalgia serve as a marker for breast cancer susceptibility?
Conclusion
Cyclical mastalgia is associated with an increased risk of breast cancer in women.
Supporting Evidence
- The adjusted Relative Risk of breast cancer was significantly increased for a total duration of oral contraceptive use longer than 72 months.
- A previous history of cyclical mastalgia was found to be associated with an increased risk of breast cancer.
- The study included 210 newly diagnosed breast cancer cases and 210 matched controls.
Takeaway
Women who have cyclical breast pain may be more likely to develop breast cancer.
Methodology
A matched case-control study comparing 210 women with breast cancer to 210 controls matched by age, education, and other factors.
Potential Biases
Potential recall bias as women diagnosed with breast cancer may report symptoms more frequently.
Limitations
The study may be subject to recall bias and selection bias.
Participant Demographics
Non-menopausal French women under 45 years old.
Statistical Information
P-Value
p<0.05
Confidence Interval
95% CI 1.31-3.43
Statistical Significance
p<0.05
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