Nonhuman Primate Models Used to Study Pelvic Inflammatory Disease Caused by Chlamydia trachomatis

2011

Using Nonhuman Primates to Study Pelvic Inflammatory Disease from Chlamydia

publication Evidence: moderate

Author Information

Author(s): Jason D. Bell, Ingrid L. Bergin, Kelsey Schmidt, Melissa K. Zochowski, David M. Aronoff, Dorothy L. Patton

Primary Institution: University of Michigan

Can nonhuman primate models effectively simulate human pelvic inflammatory disease caused by Chlamydia trachomatis?

Nonhuman primate models have significantly advanced the understanding of pelvic inflammatory disease and its treatment.

Nonhuman primates have anatomical and physiological similarities to humans, making them suitable for disease modeling.
Chlamydia trachomatis is a common cause of pelvic inflammatory disease in women.
Research using nonhuman primates has led to a better understanding of disease pathogenesis and treatment options.

Scientists use monkeys to learn about a disease that can make women infertile, helping to find better treatments.

The study reviews historical and contemporary uses of nonhuman primates in modeling chlamydial pelvic inflammatory disease.

Ethical concerns regarding vivisection and the representativeness of animal models to human disease.

Using nonhuman primates is costly and requires specialized facilities and care.

The study focuses on various nonhuman primate species, including baboons, macaques, and marmosets.

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