Prognostic Value of Myofibroblasts in Non-Invasive Bladder Cancer
Author Information
Author(s): C. G. Cañizo, F. Guerrero-Ramos, M. Perez Escavy, I. Lodewijk, C. Suárez-Cabrera, L. Morales, S. P. Nunes, E. Munera-Maravilla, C. Rubio, R. Sánchez, M. Rodriguez-Izquierdo, J. M. Martínez de Villarreal, F. X. Real, D. Castellano, C. Martín-Arriscado, D. Lora Pablos, A. Rodríguez Antolín, M. Dueñas, J. M. Paramio, V. G. Martínez
Primary Institution: University Hospital ‘12 de Octubre’, Madrid, Spain
Hypothesis
A better characterization of the tumor microenvironment composition and PD-L1 expression in NMIBC may help understand tumor biology and find new prognostic biomarkers.
Conclusion
The study highlights myoCAFs as potential prognostic markers in non-invasive bladder cancer.
Supporting Evidence
- MyoCAFs were associated with higher rates of progression and recurrence in three independent cohorts.
- The study provides a roadmap to establish the landscape of the NMIBC tumor microenvironment.
- High myoCAF abundance correlated with aggressive transcriptomic classes in multiple cohorts.
- Univariate Cox regression showed myoCAF category and score as strong predictors of progression-free and recurrence-free survival.
Takeaway
This study looked at how certain cells in bladder cancer can help predict if the cancer will come back or get worse.
Methodology
The study analyzed tumor and non-tumoral tissue biopsies from 73 NMIBC patients using scRNA-seq, transcriptomic cohorts, and tissue micro-array.
Limitations
The study was limited by the sample size and the use of only one marker to identify cell types.
Participant Demographics
Patients diagnosed with high-risk non-muscle-invasive bladder cancer, with a focus on high-grade tumors.
Statistical Information
P-Value
p<0.05
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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