Evolution of a sensory response network in nematodes
Author Information
Author(s): Srinivasan Jagan, Durak Omer, Sternberg Paul W
Primary Institution: Howard Hughes Medical Institute, Division of Biology, California Institute of Technology
Hypothesis
We speculated that cellular contribution to stereotyped avoidance behaviors would also be conserved between nematode species.
Conclusion
The study suggests that while the ASH neuron is conserved for mediating polymodal nociception, the contribution of other sensory neurons can vary among nematode species.
Supporting Evidence
- All species tested exhibit avoidance of chemo-, mechano- and osmosensory stimuli.
- Ablation of the ASH neurons resulted in an inability to avoid noxious stimuli in all species.
- In Pristionchus pacificus, the ADL neuron also contributes to osmosensation.
- Different species can increase or decrease the contribution of additional sensory neurons.
Takeaway
Nematodes have special cells that help them avoid bad things, and these cells can change a bit depending on the type of nematode.
Methodology
Comparative behavioral analysis and laser microsurgery were used to examine avoidance behaviors in six species of free-living nematodes.
Limitations
The study does not explore all possible nematode species or environmental factors that may influence sensory responses.
Participant Demographics
Six species of free-living nematodes were tested.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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