Factors Affecting Death in Trauma Patients After Blood Transfusion
Author Information
Author(s): Rangarajan Kanchana, Subramanian Arulselvi, Pandey Ravindra Mohan
Primary Institution: Jai Prakash Narayan Apex Trauma Centre, AIIMS, New Delhi, India
Hypothesis
What factors influence mortality in trauma patients receiving massive blood transfusion?
Conclusion
Mortality in trauma patients receiving massive blood transfusion is influenced by coagulopathy and low Glasgow Coma Scale scores, but not by the amount of packed red cells transfused.
Supporting Evidence
- 1.8% of transfused patients underwent massive transfusion.
- Mortality was 48% among patients receiving massive transfusion.
- High total leukocyte count and low Glasgow Coma Scale were significant predictors of mortality.
- Coagulopathy was present in 65% of nonsurvivors.
Takeaway
This study found that some patients who get a lot of blood transfusions after an injury still die, especially if they have serious bleeding problems or low alertness.
Methodology
The study analyzed records of trauma patients who underwent massive blood transfusion over a one-year period, focusing on various clinical and demographic factors.
Potential Biases
Potential biases include selection bias due to the retrospective nature of the study.
Limitations
The study is retrospective and may not account for all variables affecting mortality.
Participant Demographics
The mean age of participants was 34 years, with a majority being male and sustaining injuries from motor vehicle accidents.
Statistical Information
P-Value
p<0.01
Statistical Significance
p<0.01
Digital Object Identifier (DOI)
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