EphB2 Gene and Prostate Cancer Risk in African American Men
Author Information
Author(s): Christiane M. Robbins, Stanley Hooker, Rick A. Kittles, John D. Carpten
Primary Institution: Translational Genomics Research Institute
Hypothesis
Common variation within the EphB2 locus is associated with increased risk of sporadic prostate cancer in African American men.
Conclusion
Genetic variation at the EphB2 locus may increase the risk of sporadic prostate cancer among African American men.
Supporting Evidence
- Seven EphB2 SNPs showed statistically significant association with prostate cancer risk.
- The most significant association was for a novel synonymous coding SNP, TGen-624.
- Two SNPs showed significant associations toward a protective effect.
- Two additional SNPs revealed trends towards an increase in risk of prostate cancer.
Takeaway
This study looked at a gene called EphB2 to see if changes in it could make African American men more likely to get prostate cancer. They found some changes that seemed to protect against cancer and others that might increase risk.
Methodology
The study genotyped 341 single nucleotide polymorphisms (SNPs) in 490 sporadic prostate cancer cases and 567 matched controls.
Potential Biases
Potential population stratification could confound results.
Limitations
The sample size may limit the detection of smaller effect sizes, and some novel SNPs may have been missed.
Participant Demographics
Participants were unrelated African American men aged 40 to 85.
Statistical Information
P-Value
1×10−5
Confidence Interval
95% CI 0.08–0.66
Statistical Significance
p<0.001
Digital Object Identifier (DOI)
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