S100B Protein, Brain-Derived Neurotrophic Factor, and Glial Cell Line-Derived Neurotrophic Factor in Human Milk
2011

S100B, BDNF, and GDNF in Human Milk

Sample size: 42 publication Evidence: moderate

Author Information

Author(s): Li Ruisong, Xia Wei, Zhang Zhihong, Wu Kun

Primary Institution: Harbin Medical University

Hypothesis

What are the concentrations of S100B protein, BDNF, and GDNF in human milk and how are they associated with maternal factors?

Conclusion

S100B protein, BDNF, and GDNF are present in human milk and may influence the long-term effects of breastfeeding.

Supporting Evidence

  • S100B protein levels in human milk were positively correlated with maternal BMI.
  • BDNF and GDNF concentrations were also measured in human milk.
  • Delivery modes affected GDNF concentrations in human milk.

Takeaway

This study found important proteins in human milk that might help babies grow and develop.

Methodology

Milk samples were collected from mothers at various days after childbirth and analyzed for protein concentrations using ELISA.

Limitations

The study was limited by the small number of milk samples and the lack of maternal serum data.

Participant Demographics

Mothers aged 19 to 38 years, with a mean age of 25.26 years and BMIs ranging from 21.7 to 34.8.

Statistical Information

P-Value

0.030

Statistical Significance

p<0.05

Digital Object Identifier (DOI)

10.1371/journal.pone.0021663

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