Study of Papillary Microcarcinomas in the Thyroid Gland
Author Information
Author(s): Demet Corapcioglu, Serpil D. Sak, Tuncay Delibasi, Vedia Tonyukuk, Nuri Kamel, Ali R. Uysal, Savas Kocak, Semih Aydintug, Gurbuz Erdogan
Primary Institution: Ankara University School of Medicine
Hypothesis
What are the clinical findings, histopathological features, and p53 expression in patients with thyroid papillary microcarcinomas?
Conclusion
Thyroid papillary microcarcinomas may not be entirely benign and can show signs of poor prognosis.
Supporting Evidence
- 72% of tumors were found in the right lobe.
- 34.5% of tumors showed p53 positivity.
- Multifocality was observed in 31.7% of cases.
- Capsular invasion was present in 26.8% of tumors.
- 11.9% of patients had lymph node involvement.
Takeaway
Some tiny thyroid tumors can be more serious than they seem, showing signs that could lead to worse outcomes.
Methodology
The study included 44 patients with tumors less than 1.0 cm, evaluated for clinical, histopathological, and immunohistochemical features.
Limitations
The study was retrospective and had a small sample size.
Participant Demographics
The female/male ratio was 2.8/1, with a median age of 49 years (range 20–71 years).
Statistical Information
Statistical Significance
p > 0.05
Digital Object Identifier (DOI)
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