Effects of Gold Nanoparticles on Kidney Cells
Author Information
Author(s): Abdelhalim Mohamed Anwar K, Jarrar Bashir M
Primary Institution: King Saud University
Hypothesis
The study aims to investigate the particle-size effect of gold nanoparticles (GNPs) on renal tissue to address their potential toxicity.
Conclusion
Gold nanoparticles can cause significant histological alterations in renal tissue, indicating potential toxicity that is size-dependent.
Supporting Evidence
- Smaller gold nanoparticles induced more significant renal damage compared to larger ones.
- Histological alterations included renal tubular necrosis and inflammatory cell infiltration.
- The cortex of the kidney was more affected than the medulla due to GNPs exposure.
Takeaway
Gold nanoparticles can hurt kidney cells, especially the smaller ones, and this can happen depending on how long the cells are exposed to them.
Methodology
70 healthy male Wistar-Kyoto rats were exposed to different sizes of gold nanoparticles for 3 or 7 days to observe histological changes in renal tissue.
Limitations
The study primarily focused on histological changes without exploring long-term effects or mechanisms of toxicity.
Participant Demographics
Healthy male Wistar-Kyoto rats, approximately 12 weeks old, weighing 220-240 grams.
Digital Object Identifier (DOI)
Want to read the original?
Access the complete publication on the publisher's website