Epicardial Fat Volume and Coronary Vasomotor Response
Author Information
Author(s): Gaborit Bénédicte, Moro Pierre Julien, Flavian Antonin, Kober Frank, Jacquier Alexis, Quilici Jacques, Cuisset Thomas, Simeoni Umberto, Cozzone Patrick, Bernard Monique, Dutour Anne
Primary Institution: INSERM U626, Marseille, France
Hypothesis
Is there a relationship between epicardial fat volume and endothelium-dependent vasoreactivity in healthy subjects?
Conclusion
Increased epicardial fat volume is linked to reduced endothelial function in healthy individuals.
Supporting Evidence
- A significant increase in myocardial blood flow was observed during sympathetic stimulation.
- Mean epicardial fat volume was 82 mL, with a range from 43 to 131 mL.
- There was a significant negative correlation between epicardial fat volume and the increase in myocardial blood flow.
Takeaway
The more fat around the heart, the less well the blood vessels respond to changes, which might be a sign of future heart problems.
Methodology
Myocardial blood flow was measured using magnetic resonance imaging in response to sympathetic stimulation in healthy volunteers.
Participant Demographics
Healthy volunteers, average age 24 years, average BMI 21.1 kg/m2.
Statistical Information
P-Value
p=0.002
Statistical Significance
p<0.05
Digital Object Identifier (DOI)
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