Linking Mycobacterium avium to Type-1 Diabetes
Author Information
Author(s): Rosu Valentina, Ahmed Niyaz, Paccagnini Daniela, Gerlach Gerald, Fadda Giovanni, Hasnain Seyed E., Zanetti Stefania, Sechi Leonardo A.
Primary Institution: Università degli studi di Sassari, Sassari, Italy
Hypothesis
Is there an association between Mycobacterium avium subspecies paratuberculosis and Type-1 diabetes mellitus?
Conclusion
The study suggests that Mycobacterium avium subspecies paratuberculosis is significantly associated with Type-1 diabetes mellitus.
Supporting Evidence
- 47.3% of Type-1 diabetes patients tested positive for Mycobacterium avium compared to 12.6% of controls.
- Significant differences in antibody responses were observed between Type-1 diabetes patients and controls.
- Two strains of Mycobacterium avium were isolated from Type-1 diabetes patients.
Takeaway
Researchers found that a specific bacteria might be linked to Type-1 diabetes, which could help in diagnosing and understanding the disease.
Methodology
The study used ELISA methods to detect Mycobacterium avium in blood plasma from Type-1 diabetes, Type-2 diabetes, and non-diabetic controls.
Limitations
The study did not find significant associations in Type-2 diabetes patients, which may limit the generalizability of the findings.
Participant Demographics
57 Type-1 diabetes patients, 57 Type-2 diabetes patients, and 79 healthy controls.
Statistical Information
P-Value
p<0.0001
Statistical Significance
p<0.0001
Digital Object Identifier (DOI)
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